4D imaging of fixed and mobile knee implants.
Research type
Research Study
Full title
4D imaging of fixed and mobile knee implants: are mobile bearings mobile?
IRAS ID
200771
Contact name
Philip Riches
Contact email
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 0 months, 25 days
Research summary
The aim of the project is to compare the knee kinematics (motion of bones in the knee relative to each other) of three different bearing designs used in total knee replacement (TKR) implants. The bearing is the middle part of the knee implant that allows the metal tray attached to the shin bone (tibia) to move in relation to the metal part attached to the thigh bone (femur) and is usually made of plastic (high density polyethylene). There will be three different bearing types in the study, which all theoretically give different movements. This study will investigate which bearing creates the closest kinematics to those of a natural knee and so which bearing design gives the best functionality and feeling to patients.
Three groups of three patients each will be recruited from the patient population of the parallel study (Ref: 15\WS\0096), in collaboration with the GJNH and The Department of Biomedical Engineering at the University of Strathclyde. The patients in this parallel study are recruited and randomised to receive one of the three study bearings. For this study, three patients will be randomly selected from each group of the parallel study. Furthermore, an age-matched control group of three healthy individuals will be recruited for comparison. All the twelve participants in this study will be asked to attend one session at the Queen Elizabeth University Hospital for a 4D CT scan.
4D CT scanners are similar to conventional CT scanners with the difference that these scanners create a video of the patients' specific movements rather than the conventional static pictures. The researchers will use this opportunity to analyse how the knee anatomy and bearings being imaged articulates, which will ultimately give insight whether different bearing designs lead to improved patient kinematics. A dynamic CT analysis of the knee with an implant has not been done before.
REC name
West of Scotland REC 3
REC reference
16/WS/0182
Date of REC Opinion
4 Oct 2016
REC opinion
Favourable Opinion