4D-flow MRI in type b aortic dissection
Research type
Research Study
Full title
\nThe role of aortic haemodynamics to predict aortic events in type B aortic dissection: a 4D-flow MRI study\n
IRAS ID
294766
Contact name
Richard Gibbs
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 1 months, 31 days
Research summary
A dissection is a tear in the wall of the aorta, the largest blood vessel in the chest. It develops due to high blood pressure (BP). Treating people with medication to lower their BP means 9/10 people survive. However, by 5-years, only 50% of people are still alive, many dying because the dissected aorta develops into an aneurysm and bursts(ruptures). We don’t know why this process happens to the dissected aorta. \n\nGiven that high blood pressure is a key driver for aortic dissection and aneurysm formation, the pressure and flow of blood inside the dissected aorta may be responsible for aneurysm formation and rupture once a dissection has occured.\n\nWe will use a unique non-invasive magnetic resonance scan (MRI) to measure the flow and pressure inside the aorta to see if we can use these measures to identify which people are at most risk of aneurysm formation and aortic rupture, and will benefit from an operation to prevent aortic rupture. \n
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
21/EE/0086
Date of REC Opinion
25 Mar 2021
REC opinion
Favourable Opinion