3WINTERS-IPS

• Research type

  Research Study

• Full title

  Type 3 Von Willebrand International Registries Inhibitor Prospective Study (3WINTERS-IPS)

• IRAS ID

  146812

• Contact name

  Charles Hay

• Contact email

  charles.hay@cmft.nhs.uk

• Sponsor organisation

  Foundation "Angelo Bianchi Bonomi"

• Research summary

  Summary of results:
  The fruitful collaboration among many European and Iranian investigators participating in the 3WINTERS-IPS project has allowed collection of detailed information about VWF defects in the largest cohort of VWD3 patients available thus far, and it has helped to elucidate several differences between the EU-VWD3 and IR VWD3. There was a remarkable diversity in the degree of heterogeneity of these VWF variants. In the IR-VWD3, the number of differ ent unique variants was basically one-half the number of those identified in EU-VWD3. With only 5 exceptions, no variants were shared by the 2 populations, underlying their different genetic background. Furthermore, in the IR-VWD3, a cluster of variants was in the D9-D3 domains, whereas the EU-VWD3 variants were spread throughout the VWF. Notwithstanding these discrepancies, the spectrum of the variants identified in the two VWD3 populations was similar

• REC name

  South Central - Hampshire A Research Ethics Committee

• REC reference

  14/SC/0078

• Date of REC Opinion

  28 Feb 2014

• REC opinion

  Further Information Favourable Opinion