3T Imaging Biomarkers in Brain Tumours (3T-BIO-BT)
Research type
Research Study
Full title
3T Magnetic Resonance Imaging Biomarker Studies for Molecular Profiling in Brain Tumours
IRAS ID
354120
Contact name
Stefanie Thust
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
4 years, 9 months, 28 days
Research summary
Magnetic resonance imaging (MRI) is a helpful test to assess the brain, including for the diagnosis of tumours. MRI represents the standard test to confirm the extent of a brain tumour, how aggressive it is and to plan treatment. Many brain tumours are incurable and some, especially the common type glioblastoma, are quickly fatal. Based on recent molecular discoveries we now aim to predict detailed features such as brain tumour genetics, sites of invasion and relapse by imaging. We have developed novel MRI methods able to probe blood flow, cell density, protein content and metabolism of tumours. However, we still need to refine these techniques and combine them with laboratory science. This study applies advanced imaging with the aim to map aggressive tumour components and local relapse risk after treatment.
REC name
East of England - Essex Research Ethics Committee
REC reference
25/EE/0080
Date of REC Opinion
22 Apr 2025
REC opinion
Further Information Favourable Opinion