3rd Generation Study - Six Year Follow-Up
Research type
Research Study
Full title
THE CENTRAL ROLE OF EPIGENETICS IN MEDIATING GENETIC AND ENVIRONMENTAL RISK FOR THE DEVELOPMENT OF ASTHMA AND ALLERGIC DISEASE IN CHILDHOOD - ASSESSMENT AT 6-7 YEARS OF AGE
IRAS ID
213170
Contact name
Syed Hasan Arshad
Contact email
Sponsor organisation
St Mary's Hospital - NHS Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
This study will follow up the 3rd Generation Study participants at 6-7 years of age. The 3rd Generation Study is a birth cohort born to participants of the 1989/90 Isle of Wight Birth Cohort Study. The 3rd Generation participants have been seen during infancy when information about the environmental exposures including microbial exposure and epigenetics (chemical markings on DNA) has been collected. This study aims to determine if pre- and post-natal exposures influence the development of asthma and lung function and if this is through alternation of DNA methylation. Because asthma cannot be diagnosed with certainty before the age of 6 years, we propose to follow-up of these children to reassess them at 6 years of age. It is at this age that spirometry can be done reliably and reproducibly which is traditionally used to assess lung function and airway obstruction, a hallmark of asthma.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
17/EM/0083
Date of REC Opinion
12 Apr 2017
REC opinion
Further Information Favourable Opinion