3D Ultrasound for Carotid Stenosis: Accuracy & Decision Support
Research type
Research Study
Full title
Evaluating the Diagnostic Accuracy and Volumetric Utility of 3D Ultrasound for Carotid Artery Stenosis Assessment and Decision Support: CAVES Study
IRAS ID
347632
Contact name
Alun Davies
Contact email
Sponsor organisation
Imperial College Healthcare NHS Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Carotid artery stenosis (CAS) is a condition where the arteries in the neck become narrowed due to the build-up of fatty deposits (plaque), which can reduce blood flow to the brain and lead to stroke. Around 20% of strokes are caused by CAS. Early and accurate diagnosis is key to preventing stroke and improving patient outcomes.
The current standard test, called Duplex ultrasound (DUS), measures blood flow and looks at how narrow the artery has become. However, DUS only captures two-dimensional (2D) images and does not show full shape and size of the plaque. This can make it harder to judge how serious the narrowing is. This study will explore whether a three-dimensional (3D) ultrasound scan, using CE-marked equipment within its
intended purpose but not yet routinely adopted for grading carotid artery stenosis in UK clinical pathways, can provide better detail about the plaque’s volume, shape, and surface features. The aim is to improve the accuracy of diagnosis and support better treatment decisions. Patients already having a DUS scan as part of their normal care will be invited to have a short 3D scan during same appointment. Some patients may also have had a CTA scan, requested by their doctor before joining study. No extra scans will be ordered for this research.The study will also test computer models (artificial intelligence) that automatically assess plaque features and predict clinical outcomes, including stroke risk or disease progression. This study will assess stakeholder perceptions of the clinical utility and usability of 3D ultrasound, helping to identify practical considerations for its adoption into routine diagnostic practice. 131 patients will take part across two NHS hospitals in London. This study is part of a PhD at Imperial College London and is partially funded by the NIHR i4i FAST programme. Findings may support wider use of 3D ultrasound in stroke prevention.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
25/EE/0169
Date of REC Opinion
31 Jul 2025
REC opinion
Further Information Favourable Opinion