31P Validation Study
Research type
Research Study
Full title
Development and Validation of a Cardiac 31Phosphorus Magnetic Resonance Spectroscopy Protocol In Heart Failure Patients
IRAS ID
232628
Contact name
Darlington O Okonko
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
In this study we will recruit patients with Heart Failure, who have reduced function of the main pumping chamber of the heart. They will undergo MRI scanning of the heart with a specific sequence to measure levels of phosphorus containing molecules in the heart. This technique is called 31-Phosphorus Magnetic Resonance Spectroscopy, and measures the ability of the heart to generate energy. Impaired energetics of the heart has been shown to correlate with mortality.
We will compare cardiac energetics in heart failure patients to that of healthy volunteers to ensure our technique is accurate enough to distinguish the two. In addition we will perform a comparison of cardiac energetics in heart failure patients who are iron deficient to those who are not.
The technique is extremely useful to assess mitochondrial function in-vivo in humans, and is currently only offered by two centres in England (Oxford and Newcastle). The study will demonstrate that the technique of 31P-MRS is feasible in our centre, with acceptable signal to noise ratio (SNR), in this cohort of patients. This will allow groups interested in studying cardiac energetics to access this powerful technique for the benefit of patients.
REC name
London - Queen Square Research Ethics Committee
REC reference
17/LO/1740
Date of REC Opinion
29 Dec 2017
REC opinion
Further Information Favourable Opinion