23Na MRI in HD
Research type
Research Study
Full title
23Na Magnetic Resonance Imaging in Haemodialysis
IRAS ID
231668
Contact name
Nicholas Selby
Contact email
Sponsor organisation
Royal Derby Hospital
Clinicaltrials.gov Identifier
REC, REC 3 18/WS/0043
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Most forms of magnetic resonance imaging (MRI) are based on the principle that water molecules behave in a certain way when they are placed in strong magnetic field. Most tissues in the human body contain water but in different amounts and held in different arrangements; MRI takes advantage of this to generate images of different tissues.
A new form of MRI has been developed, that is able to measure the behavior of sodium (Na) atoms, instead of water molecules. This allows MRI to measure the amount of sodium in different tissues of the body. This is important as sodium is an important marker of tissue health and is important in blood pressure. Now that 23Na MRI has been established as a technique, we wish to establish whether it is useful in patients receiving haemodialysis for end stage kidney disease (ESKD). In particular, we aim to use 23Na-MRI to measure sodium content of skin and muscle and see how these measures relate to blood pressure and volume status.REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
18/EM/0095
Date of REC Opinion
3 May 2018
REC opinion
Further Information Favourable Opinion