[18F]FPIA PET/CT imaging in patients with solid tumours
Research type
Research Study
Full title
An investigation of short-chain fatty acid uptake in solid tumours as assessed by [18F]fluoropivalate positron emission tomography and its relationship with tumour proliferation.
IRAS ID
284882
Contact name
Tara Barwick
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
Z6364106/2020/11/68, UCL Data Protection Registration Number
Duration of Study in the UK
1 years, 11 months, 28 days
Research summary
Cancers have increased energy demands to allow for their rapid growth compared to healthy cells. Glucose is the main source of energy for many cells in the body, and we routinely use a scan which looks at glucose metabolism to assess if cancer treatment is working. However, some cancer cells can create energy to survive and grow in a different way, using fatty acids. In this study, we are using a PET/CT scan to look at a variety of cancer types to see which cancers use fatty acids for energy and if we can measure it. The PET/CT scan will be carried out twice on 2 separate visits so that we can check that both scans give us the same result.
We will also carry out special tests on the tumour tissue taken during routine cancer surgery. These tests will look for specific substances in the cancer cells that are related to cancer biology and growth. We will then compare the results from the surgical tissue to the results of the scan to see if there is a relationship between them.
We will look at 21 patients with solid tumours conducted in 4 NCITA accredited centres, which have different strengths in recruiting specific patient/tumour-type cohorts. Each patient will have two scan visits (between 2-15 days apart) prior to any new treatment starting to check that the scan measurements are repeatable.REC name
South Central - Hampshire B Research Ethics Committee
REC reference
21/SC/0090
Date of REC Opinion
11 May 2021
REC opinion
Further Information Favourable Opinion