18F-LW223
Research type
Research Study
Full title
18F-LW223: a superior TSPO PET radiotracer for a clinical breakthrough to detect regional tissue inflammation
IRAS ID
1007539
Contact name
David Newby
Contact email
Sponsor organisation
University of Edinburgh
ISRCTN Number
ISRCTN33793580
Research summary
This project will study a new tool for scanning patients based on a highly specialised scanning technique called positron emission tomography (PET). PET allows for the study of different processes happening inside the human body by injecting a small amount of a substance into patients, i.e. a radiotracer. Our new radiotracer, [18F]LW223, was designed so it can highlight and localise inflammation inside the body. This could be useful, as inflammation plays a role in the development and progression of many common diseases.
In this study, we will be tracking [18F]LW223 signal inside the human body over time, in 27 healthy male individuals aged between 18 and 55. This will involve a single PET scan for each healthy volunteer. During the scan we will collect blood and/or urine samples, to work out the best dose and to ensure [18F]LW223 signal is consistent across the population along with ensuring safety and tolerability of the compound within healthy volunteers.
The study is being funded by the Medical Research Council (MRC) and will be conducted at the Royal Infirmary of Edinburgh.
REC name
North East - York Research Ethics Committee
REC reference
25/NE/0170
Date of REC Opinion
15 Oct 2025
REC opinion
Further Information Favourable Opinion