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Approved COVID-19 research

Last updated on 22 May 2020

We know that sharing information about approved COVID-19 studies is important to ensure researchers and sponsors know about other studies taking place across the UK. It also gives the public, healthcare professionals and policy makers insight into what research is happening to better understand and manage the virus and treat the infection. 

We already publish information about approved projects on our Research Summaries tool but for COVID-19 research we are fast tracking this publication. 

We will continue to add new studies as they are approved and where appropriate, work with the research team to revise the research summary, after they are published, to make sure they are accessible and easy to understand. We aim to publish all studies three working days after they're approved. 

Some of the studies we approve are categorised as Urgent Public Health Research Studies for COVID-19. You can find a list of these studies on the NIHR website.

Below is a list of all COVID-19 research that’s been approved by a Research Ethics Committee (REC).  


CORonavirus (COVID-19) Diagnostic Lung UltraSound Study
IRAS ID: 282661
Approval date: 29/04/2020


Sample and data collection for cardiovascular research 
IRAS ID: 31239
Approval date: 29/04/2020

REal-time Assessment of Community Transmission 2 (REACT 2): Usability and feasibility study of widespread home self-testing for SARS-CoV-2 antibodies
IRAS ID: 283805
Date: 29/04/2020
Urgent public health research study for COVID-19


CHARIOT: Cognitive Health in Ageing Register: Investigational, Observational and Trial studies in dementia research
IRAS ID: 204444
Approval date: 29/04/2020


The UK Renal Registry
IRAS ID: 199545
Approval date: 29/04/2020

A pilot study exploring the immune signature of Gram+ bacterial infections in the bloodstream of septic patients
IRAS ID: 269597
Approval date: 29/04/2020


Longitudinal population-based observational study of coronavirus disease in the UK population 
IRAS ID: 281648
Approval date: 28/04/2020


REal-time Assessment of Community Transmission (REACT) - Antigen testing
IRAS ID: 283787
Approval date: 28/04/2020
Urgent public health research study for COVID-19


Phase 3 multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of canakinumab on cytokine release syndrome in patients with COVID-19-induced pneumonia (CAN-COVID)
IRAS ID: 282416
Approval date: 28/04/2020
Urgent public health research study for COVID-19


Phase 3 randomised, double-blind, placebo-controlled study to assess the efficacy and safety of ruxolitnib in patients with COVID-19 associated cytokine storm
IRAS ID: 282417
Approval date: 28/04/2020
Urgent public health research study for COVID-19


Haemostasis research on discarded plasma samples from patients with COVID-19
IRAS number: 283050
Approval date: 27/04/2020


Covid-19 Psychiatry and Neurological Genetics study in the NIHR BioResource, GLAD, EDGI and other recontactable cohorts 
IRAS ID: 282754
Approval date: 27/04/2020


Measuring changes in Need for Recovery of frontline clinical staff deployed to work at NHS Nightingale Hospital (North West) during the COVID-19 pandemic
IRAS ID: 283022
Approval date: 27/04/2020


COVID-19 infection in patients with haematological disorders
IRAS ID: 282997
Approval date: 27/04/2020

The Living Airway Biobank (LAB)
IRAS ID: 261511
Approval date: 27/04/2020


NHS CHECK: Health & Experiences of staff working at NHS Trusts and Nightingale Hospitals
IRAS ID: 282686
Approval date: 24/04/2020


Integrated Network for Surveillance, Trials and Investigations into COVID-19 Transmission (INSTINCT)
IRAS ID: 282820 
Approval date: 24/04/2020


Rapid diagnosis of COVID-19 positive patients with Artificial Intelligence (AI) algorithm using clinical and image analytical parameters to evaluate the lymphocyte subsets in the peripheral blood
IRAS ID: 281667
Approval date: 24/04/2020


The 'COVID-19 CPAP CTEX-WG5 Ventilator' Multi-site device investigation 
IRAS ID: 282487
Approval date: 24/04/2020


Cardiac manifestations of COVID-19 in patients admitted to hospital
IRAS 1D: 282485
Approval date: 24/04/2020


COST NHS: COvid burden for STaff working in the NHS. A study to assess the mental health burden of the COVID-19 pandemic on NHS healthcare staff
IRAS ID: 282467
Approval date: 24/04/2020


The SOAP study: Sars-CoV-2 for Cancer Patients Immunological consequences of COVID-19 for cancer patients
IRAS ID: 282337
Approval date: 24/04/2020


ACCORD-2-001: Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID 19 in Hospitalised Patients ACCORD-2-002: Sub protocol for Candidate Agent: Bemcentinib
IRAS ID: 282769
Approval date: 24/04/2020
Urgent public health research study for COVID-19


Screening for asymptomatic SARS-CoV-2 infection in term parturients and health workers in maternity care: a cross-sectional, observational study
IRAS ID: 283049
Approval date: 23/04/2020


COVID-19 Staff Testing of Antibody Responses Study (CO-STARS)
IRAS ID: 282713
Approval date: 23/04/2020


Evaluation of host and microbial factors in discard respiratory sample
IRAS ID: 282319
Approval date: 23/04/2020


UK Biobank: a large scale prospective epidemiological resource of 500,000 people aged 40-69 from around the UK
IRAS ID: 200778
Approval date: 23/04/2020


Human immune responses to Zika virus and other flaviviruses
IRAS ID: 202413
Approval date: 23/04/2020


Multi-Morbidity in Older Adults with Depression (MODS): Work Stream 1 (WS1)
IRAS ID: 249030
Approval date: 23/04/2020


Rapid COVID-19 Intelligence to improve primary care response 
IRAS ID: 282541 
Approval date: 22/04/2020


NIHR BioResource
IRAS ID: 220277
Approval date: 22/04/2020

Caring in a Crisis: Understanding the stressors and uplifts for NHS frontline staff and those supporting them during Covid-19 crisis
IRAS ID: 282770
Approval date: 22/04/2020

A prospective non interventional study to evaluate the role of immune and inflammatory response in recipients of allogeneic haematopoietic stem cell transplantation (SCT) affected by severe COVID19 infection
IRAS ID: 282229
Approval date: 22/04/2020

An observational study to examine the clinical utility and acceptance of SARS-CoV-2 serology testing in convalescent patients to establish their role in identifying individuals with prior exposure to infection
IRAS ID: 282525
Approval date: 22/04/2020

Panbio™ COVID-19 IgG/IgM Rapid Test Device Matrix Equivalence Study
IRAS ID: 283040
Approval date: 22/04/2020

Early biomarkers for ARthritic PAIN to guide improved treatments for arthritis (ARPAIN) study
IRAS ID: 234659
Approval date: 22/04/2020


The Covid-19 & Stress Study
IRAS ID: 282935
Approval date: 21/04/2020

Mapping Organ Health in Recovery from COVID-19 Disease due to SARS-CoV-2 infection
IRAS ID: 282636
Approval date: 21/04/2020

COVID 19 in haemodialysis patients; clinical characteristics, risk factors and outcomes
IRAS ID: 283130
Approval date: 21/04/2020

Macro and microcirculatory haemodynamic responses to shock in the renal and systemic circulations; a prospective longitudinal observational study
IRAS ID: 246076
Approval date: 20/04/2020


Activating Resilience: Mobilising Responses to COVID-19 within Nightingale Hospitals
IRAS ID: 282761
Approval date: 20/04/2020

Born in Bradford's Growing up Family Study
IRAS ID: 207543
Approval date: 20/04/2020

BiB4All: A data linkage cohort study of babies born in Bradford and their mothers
IRAS ID: 226266
Approval date: 20/04/2020

Oxford Radcliffe Biobank
IRAS ID: 262470
Approval date: 17/04/2020


National COVID-19 Chest Imaging Database (NCCID) v1.0
IRAS ID: 282365
Approval date: 17/04/2020

Born in Bradford's Better Start Cohort Study. A cohort study of babies born in Bowling and Barkerend, Bradford Moor and Little Horton areas of Bradford, and their mothers and partners
IRAS ID: 188581
Approval date: 17/04/2020

ChemoPROphyLaxIs For covId-19 infeCtious disease (the PROLIFIC trial)
IRAS ID: 281919
Approval date: 17/04/2020


COPE Study: COVID-19 in Older PEople - the influence of frailty and multimorbidity on survival. A multicentre, international observational study
IRAS ID: 281951
Approval date: 17/04/2020


A pilot, open label, phase II clinical trial of nebulised recombinant tissue-Plasminogen Activator (rt-PA)in patients with COVID-19 ARDS: The Plasminogen Activator COVID-19 ARDS (PACA) trial
IRAS ID: 282600
Approval date: 17/04/2020


Haematological abnormalities in COVID-19
IRAS ID: 281880
Approval date: 16/04/2020

An observational cohort study to explore patient outcome from heart surgery during the Covid-19 pandemic (CardiacCovid)
IRAS ID: 282411
Approval date: 16/04/2020

Adapting Palliative Care under a Pandemic (APCuP)
IRAS ID: 282846
Approval date: 16/04/2020

MABRA Multiscale analysis of B cell responses in Ageing
IRAS ID: 155921
Approval date: 16/04/2020

COVID-19 hyperinflammation syndrome (COV-HI): protocol for a rapidly executed cohort study
IRAS ID: 282626
Approval date: 15/04/2020

Specimen Collection for Development and Performance Evaluation of the LumiraDx Platform Point of Care Tests for Sars-Cov-2 IgG/IgM & Antigen to be used as an Aid in Diagnosis of COVID-19
IRAS ID: 282521
Approval date: 15/04/2020

PsoProtect (Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of Covid-19 infecTion)
IRAS ID: 282395
Approval date: 15/04/2020


Sequencing and Tracking Of Phylogeny in Covid-19 study (STOP Covid-19)
IRAS ID: 282394
Approval date: 15/04/2020

Development of tools for quality assessment, quantification and outcome prediction from echocardiographic images
IRAS ID: 251473
Approval date: 15/04/2020

Immunohistological Research in Primary Systemic Vasculitis (IRVAS)
IRAS ID: 194217
Approval date: 15/04/2020


Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis
IRAS ID: 278651
Approval date: 14/04/2020
Urgent public health research study for COVID-19

Investigation of SARS-CoV2 excretion in faeces
IRAS ID: 282681
Approval date: 14/04/2020

The Psychosocial, Relational and Emotional Consequences of Occupational Trauma Exposure During and Following A Pandemic: Insights from NHS Emergency Ambulance Personnel in England
IRAS ID: 282650
Approval date: 14/04/2020

Newcastle Biobank
IRAS ID: 233551
Approval date: 14/04/2020

Bariatric Surgery: The Role of Intestinal Versus Gastric Mechanisms in the Regulation of Dietary Intake, Body Weight and Metabolism
IRAS ID: 255980
Approval date: 09/04/2020

The PanSurg-PREDICT Study
IRAS ID: 282351
Approval date: 09/04/2020

Pregnancy and Neonatal Outcomes in COVID-19: A global registry of women with suspected or confirmed SARS-CoV-2 infection in pregnancy and their neonates, understanding natural history to guide treatment and prevention
IRAS ID: 282655
Approval date: 09/04/2020
Urgent public health research study for COVID-19

Clinical characteristics, disease severity and need for non-invasive or invasive ventilation in paediatric inpatients with COVID-19 at Northwick Park Hospital
IRAS ID: 282609
Approval date: 09/04/2020

London Ambulance Service Experience of COVID-19
IRAS ID: 282296
Approval date: 09/04/2020


A feasibility study on integrating home-based metacognitive therapy for anxiety and depression in the cardiac rehabilitation pathway (PATHWAY STUDY 3)
IRAS ID: 186990
Approval date: 09/04/2020

An investigation describing the Long and Short-Term effects of Standard-of-Care treatments for people with Cancer
IRAS ID: 193937
Approval date: 09/04/2020

A PHASE II OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND TOLERABILITY OF UTTR1147A IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS OR CROHN'S DISEASE
IRAS ID: 242927
Approval date: 09/04/2020


A Randomized, Double Blind, Placebo Controlled, First-in-Human Study Designed to Evaluate the Safety, Tolerability, and Pharmacokinetics of EIDD-2801 Following Oral Administration to Healthy Volunteers
IRAS ID: 282287
Approval date: 08/04/2020


BioResource in Adult Infectious Disease (2019-2024)
IRAS ID: 259776
Approval date: 09/04/2020

Rapid diagnostics, antibody testing and host response in children with Covid-19 (RAPID-19)
IRAS ID: 282617
Approved: 08/04/2020

Facilitating A SARS CoV-2 TEst for Rapid triage (FASTER)
IRAS ID: 282147
Approval date: 08/04/2020

ESMI-II: The Effectiveness and cost effectiveness of community perinatal Mental health services
IRAS ID: 265175
Approval date: 08/04/2020

Wales Cancer Bank (COVID 19 amendment)
IRAS ID: 212107
Approval date: 08/04/2020

A Multi-center, Multi-country Retrospective Cohort Study to Evaluate the Clinical Outcomes in Adults with Severe COVID- 19
IRAS ID: 282652
Approval date: 07/04/2020

A retrospective, observational analysis using Real Time Location Systems (RTLS) technology to explore the effects of clinical staffing on hospital productivity and patient health outcomes
IRAS ID: 272928
Approval date: 07/04/2020


How to Support cHildren with cAncer and theiR parents during the COVID-19 outbreak?: understanding Experiences, information and support needs, and decision-making – the SHARE study
IRAS ID: 282176
Approval date: 06/04/2020

Identifying and explaining clusters of acute physical and mental health conditions in the East Midlands of the UK and Ontario using ambulance call condition data: SatScan analysis and evaluation of health care system effectiveness
IRAS ID: 264573
Approval date: 06/04/2020

A randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and efficacy of tocilizumab in patients with severe covid-19 pneumonia
IRAS ID: 282099
Approval date: 06/04/2020
Urgent public health research study for COVID-19

PROTECT: A Platform for Research Online to Investigate Cognition and Genetics in Ageing
IRAS ID: 136118
Approval date: 06/04/2020

The detection of bacterial products and the effects on patients in infection 
IRAS ID: 162013
Approval date: 06/04/2020

The Impact of using FilmArray Pneumonia Panel Molecular Diagnostics for Hospital-Acquired and Ventilator-Associated Pneumonia on Antimicrobial Stewardship and Patient Outcomes in UK Critical Care: A Multicentre Randomised Controlled Trial.
IRAS ID: 250289
Approval date: 06/04/2020

Paramedic Experiences of providing Care during the 2020 COVID-19 Pandemic (PECC-19): A qualitative study using Grounded Theory
IRAS ID: 282623
Approval date: 04/04/2020


De-coding COVID-19
IRAS ID: 282225
Approval date: 03/04/2020

Ventilation Strategies in COVID-19; CPAP, High-flow, and standard care (RECOVERY - Respiratory Support)
IRAS ID: 282338
Approval date: 03/04/2020
Urgent public health research study for COVID-19

Remote Assessment of Disease And Relapse in Major Depressive Disorder
IRAS ID: 218215
Approval date: 03/04/2020

Understanding and modelling COVID-19 mortality and severity using Electronic Health Record data: An observational cohort study
IRAS ID: 281766
Approval date: 03/04/2020


The COVID-19 Vascular sERvice Study
IRAS ID: 282224
Approval date: 03/04/2020

Open Coronavirus Research Platform - Phase I: Retrospective analyses of healthcare records for patients hospitalised with COVID-19
IRAS ID: 282148
Approval date: 02/04/2020

An adaptive Phase 2/3, randomized, open-label study assessing efficacy and safety of hydroxychloroquine for hospitalized patients with moderate to severe COVID-19 
IRAS ID: 282362
Approval date: 02/04/2020

COVIDx: Evaluation of novel diagnostic tests for 2019-nCOV
IRAS ID: 282168
Approval date: 02/04/2020

A rapid appraisal of healthcare workers’ perceptions of care delivery in the context of the COVID-19 pandemic
IRAS ID: 282069
Approval: 02/04/2020

The Impact of COVID19 on patients with renal disease including renal transplant patients and dialysis patients
IRAS ID: 282077
Approval date: 02/04/2020

Development and Assessment of Rapid Testing for SARS-CoV-2 outbreak (DARTS)
IRAS ID: 282104
Approval date: 02/04/2020


Software innovation Lifelight to help in the management and initial assessment of patients with suspected COVID-19 by extracting NEWS2 data remotely
IRAS ID: 281533
Approval date: 02/04/2020


Imperial Health Knowledge Bank 
IRAS ID: 256428
Approval date: 02/04/2020

CFHealthHub Data Observatory: A quality improvement project and Trials Within Cohort platform for Cystic Fibrosis
IRAS ID: 216782
Approval date: 01/04/2020

The COVID-19 Ambulance Response Assessment Study (CARA)
IRAS ID: 282314
Approval date: 31/03/2020

Manchester Allergy, Respiratory & Thoracic Surgery Biobank 
IRAS ID: 180280
Approval date: 31/03/2020

Donate for Research Initiative (DRI) 
IRAS ID: 236016
Approval date: 30/03/2020


COVID19 and Diabetes: A Continuous Glucose Monitoring Study of Risk and Intervention in the Intensive Care Unit
IRAS ID: 282034
Approval date: 30/03/2020

Rapid European SARS-COV-2 Emergency research Response (RECOVER): Qualitative interviews with patients and healthcare professionals
IRAS ID: 281980
Approval date: 30/03/2020 


Assessment of rubella titres in COVID-19 patients
IRAS ID: 282308
Approval date: 30/03/2020

Neonatal Complications of Coronavirus Disease (COVID-19) Study
IRAS ID: 282127
Approval date: 30/03/2020
Urgent public health research study for COVID-19

Non inferiority trial for detection of nCOVID-19 through analysis of exhaled breath aerosols
IRAS ID: 237557
Approval date: 30/03/2020

Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) trial: An open label dose escalation phase 1 trial followed by a randomised, double-blind, placebo-controlled phase 2 trial
IRAS ID: 227090
Approval date: 30/03/2020
Urgent public health research study for COVID-19

REmote MOniToring usE in suspected cases of COVID-19 (coronavirus): REMOTE-COVID trial
IRAS ID: 281757
Approval date: 27/03/2020

DIagnostic and Severity markers of COVID-19 to Enable Rapid triage (DISCOVER) study
IRAS ID: 282116
Approval date: 27/03/2020

A multicenter, adaptive, randomized blinded controlled trial of the safety and efficacy of investigational therapeutics for the treatment of COVID-19 in hospitalised adults
IRAS ID: 281800
Approval date: 27/03/2020
Urgent public health research study for COVID-19 

ONCOVID: natural history and outcomes of cancer patients during the COVID19 epidemic
IRAS ID: 282140
Approval date: 26/03/2020


Computer analysis of novel coronavirus chest imaging
IRAS ID: 282063
Approval date: 26/03/2020

Preventing Cardiac Complication of COVID-19 Disease with Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial
IRAS ID: 281827
Approval date: 26/03/2020


SARS-CoV-2 Acquisition in Frontline Health Care Workers – Evaluation to Inform Response (SAFER)
IRAS ID: 281836
Approval date: 26/03/2020


Platform Randomised trial of INterventions against COVID-19 In older peoPLE [PRINCIPLE]
IRAS ID: 281958
Approval date: 26/03/2020
Urgent public health research study for COVID-19 

A phase I/II study to determine efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19 in UK healthy adult volunteers
IRAS ID: 281259
Approved: 26/03/2020
Urgent public health research study for COVID-19 

A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants with Moderate COVID-19 Compared to Standard of Care Treatment
IRAS ID: 282026
Approval date: 25/03/2020
Urgent public health research study for COVID-19 

A Phase 3 Randomized Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants with Severe COVID-19
IRAS ID: 282007
Approval date: 25/03/2020
Urgent public health research study for COVID-19 


Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia [REMAP-CAP]
IRAS ID: 237150
Approval date: 24/03/2020
Urgent public health research study for COVID-19

Rapid and sensitive detection of SARS-CoV-2 using a nucleic acid based lab-on-a-chip diagnostic platform
IRAS ID: 281975
Approval date: 24/03/2020

Early identification of COVID-19 from undifferentiated medical presentations using Machine Learning
IRAS ID: 281832
Approval date: 24/03/2020


Examining T cell responses in virus infection (ExCel)
IRAS ID: 280217
Approval date: 24/03/2020

Genetics of susceptibility and mortality in critical care (GenOMICC)
IRAS ID: 269326 & 189676
Approval date: 23/03/2020

Innate-like T cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immunosuppression
IRAS ID: 231993
Approval date: 20/03/2020

COVID-19: Healthcare worker Bioresource: Immune Protection and Pathogenesis in SARS-CoV-2
IRAS ID: 281844
Approval date: 19/03/2020

COVID-19 Emergency Response Assessment (CERA)
IRAS ID: 281944
Approval date: 18/03/2020


Investigating and forecasting the impact of Covid-19 on Emergency Departments
IRAS ID: 281881
Approval date: 18/03/2020

Incidence and Pathogenesis of Invasive Aspergillosis in Intensive Care Patients with Severe Influenza (AspiFLu)
IRAS ID: 271269
Approval date: 18/03/2020

Randomised Evaluation of COVID-19 Therapy (RECOVERY) 
IRAS ID: 281712
Approval date: 17/03/2020
Urgent public health research study for COVID-19 

Coronavirus infection in primary or secondary immunosuppressed children
IRAS ID: 281544
Approval date: 17/03/2020
Urgent public health research study for COVID-19


A randomised double-blind placebo-controlled trial to determine the safety and efficacy of inhaled SNG001 (IFNβ-1a for nebulisation) for the treatment of patients with confirmed SARS-CoV-2 infection
IRAS ID: 281317
Approval date: 17/03/2020
Urgent public health research study for COVID-19

A crossover, cluster randomised controlled trial of Selective Decontamination of the Digestive Tract in Intensive Care Unit patients
IRAS ID: 227201
Approval date: 16/03/2020

Evaluating the clinical impact of routine molecular point-of-care testing for COVID-19 in adults presenting to hospital: A prospective, interventional, non-randomised pre and post implementation study (CoV-19POC)
IRAS ID: 280621
Approval date: 16/03/2020

Delirium and Population Health Informatics Cohort (DELPHIC) Study 
IRAS ID: 164446
Approval date: 16/03/2020

Pandemic Respiratory Infection Emergency System Triage [PRIEST]
IRAS ID: 101138
Approval date: 11/03/2020
Urgent public health research study for COVID-19 

The GAinS investigators: application of an integrated immune -omic approach in sepsis
IRAS ID: 260007
Approval date: 06/03/2020

Maternal and perinatal outcomes of pandemic influenza or novel coronavirus (COVID-19) in pregnancy [UKOSS]
Approval date: 02/03/2020
Urgent public health research study for COVID-19 
IRAS ID: 112935


Sero-epidemiological survey of England in 2019/2020 [What't the STORY]
IRAS ID: 263097
Approval date: 25/02/2020
Urgent public health research study for COVID-19

Novel Coronavirus Observational Study
IRAS ID: 126600
Approval date: 24/02/2020
Urgent public health research study for COVID-19


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