Intrinsic PEEP and laryngeal aperture in COPD

• Research type

  Research Study

• Full title

  An investigation into the pressure and airflow/volume changes which accompany partial closure of the larynx during expiration in patients with Chronic Obstructive Pulmonary Disease (COPD) and the effect of applying a positive end expired pressure by facemask on these parameters.

• IRAS ID

  163863

• Contact name

  Michael Polkey

• Contact email

  m.polkey@rbht.nhs.uk

• Sponsor organisation

  Royal Brompton & Harefield NHS Foundation Trust

• Duration of Study in the UK

  1 years, 11 months, 29 days

• Research summary

  In this study we aim to investigate the extent to which, in patients with chronic obstructive pulmonary disease (COPD), narrowing of the vocal cords causes a positive pressure within the airways thus improving expiratory airflow and lung function. This information will be captured in the upright and lying down positions and an estimate of the magnitude of the effect will be formed by offsetting the pressure by asking the patients to breathe using a commercially available device used to treat Obstructive Sleep Apnoea called a CPAP machine.

  We believe the information gained will be useful in the desgn of devices used to treat chronic rerspiratory failure in COPD

• REC name

  London - Dulwich Research Ethics Committee

• REC reference

  15/LO/0047

• Date of REC Opinion

  30 Jan 2015

• REC opinion

  Favourable Opinion