Imaging in childhood uveitis

  • Research type

    Research Study

  • Full title

    OCT imaging for the eyes of children with or without uveitis

  • IRAS ID

    258724

  • Contact name

    Ameenat Lola Solebo

  • Contact email

    lola.solebo@gosh.nhs.uk

  • Sponsor organisation

    UCL GOS ICH

  • Clinicaltrials.gov Identifier

    Z6364106/2019/03/208 , UCL Data protection

  • Duration of Study in the UK

    6 years, 0 months, 1 days

  • Research summary

    Paediatric uveitis (inflammation inside the eye) is an uncommon disorder which carries the risk of blindness. In the most common form of the disorder, anterior uveitis, the front chamber of the eye is affected. Inadequate treatment of active inflammation has been shown to be related to poor outcome. Currently, disease activity is assessed using bio-microscopic examination of the anterior chamber of the eye, undertaken by an ophthalmologist (eye doctor), who grades the degree of inflammation using an internationally agreed scale. This scale has not been validated for use in children, and when used in adults it is open to considerable variability between doctors.
    A new adaptation of an existing imaging technology, optical coherence tomography, has been shown to be able to detect and measure inflammation inside the eye in animal studies and small pilot studies in adults. Another new adaptation, OCT angiography, can image blood flow within the different tissues in the eye. OCT cameras are in common clinical use to assess inflammation in the back of the eye (choroid and retina). A previous pilot study (215685, REC 18/LO/0252) has demonstrated the feasibility of OCT/A image capture in children. We now aim to validate OCT detection of anterior chamber activity, and OCTA classification of disease type, in children.

  • REC name

    South Central - Oxford B Research Ethics Committee

  • REC reference

    19/SC/0283

  • Date of REC Opinion

    12 Jun 2019

  • REC opinion

    Further Information Favourable Opinion