Home Actigraphy in MS

Full title A PILOT STUDY OF HOME ACTIGRAPHY MONITORING IN MS
Research type Research study
IRAS ID 171121
Contact Name Paul Matthews
Contact Email paul.m.matthews@gsk.com
Sponsor organisation Joint Research Compliance Office , Charing Cross Hospital Fulham Palace Road, London,
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Clinicaltrials.gov identifier
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Research summary Tools for sensitive assessment of clinically meaningful measures of disability and its progression in people with multiple sclerosis (MS) are needed. Doctors find it difficult to appreciate fluctuations in disability from day-to-day that can be important to people with MS from only the occasional measures able to be conducted during clinic visits. Therefore, we need tools to monitor disability and its changes in the home environment.

Walking speed reflects a dimension of disability important to people with MS that is recognised as an outcome for clinical trials. Actigraphy-using simple “watch-sized” sensors of movement that people can wear- holds promise for assessment of walking speed of people with MS wherever they are, automatically. However, these methods have not been widely applied in MS. A reason for this is that the interpretation of the actigraphy signal changes with differences in the way people walk as they experience different degrees of disability. We believe it is possible to “tune” the method individually and provide a quantitative measure suitable for each person, regardless of their disability, if they are still able to walk.

We propose to design a simple actigraphy device that could be used comfortably over many days by people with MS to help their doctors measure how they are walking in their home environment. We will develop ways of calibrating the device and then analysing the signal to provide an accurate measure of walking for each person. Finally, we will explore how the measurements relate to the measures of disability usually used by doctors.
REC Name London - Bromley Research Ethics Committee
REC Reference 15/LO/0292
REC Opinion

Favourable Opinion

Favourable Opinion

Date of REC Opinion 24 February 2015