Cortisol PD AD

Full title Innovative measurements for improved diagnosis and management of neurodegenerative diseases (NDD) - Subproject to validate LGC’s assays for free and bound cortisol as a surrogate objective measure of anxiety in people with Parkinson’s and Alzheimer's disease.
Research type Research study
IRAS ID 201740
Contact Name Katherine H O Deane
Contact Email k.deane@uea.ac.uk
Sponsor organisation University of East Anglia
Eudract number
ISRCTN number
Clinicaltrials.gov identifier
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Research summary Stress and anxiety are common problems for people who have Parkinson’s or Alzheimer’s disease. Measuring stress and anxiety is hard in people with these conditions because the symptoms of Parkinson’s or Alzheimer’s can be confused with stress and anxiety, and because sometimes it’s hard for people with these conditions to report on their symptoms. There is a hormone called cortisol that is released when people are stressed or anxious. It can also be affected by sleep problems, medications and the time of day. We want to see if measuring the levels of cortisol in people’s blood is a good measure for stress and anxiety in people with Parkinson’s or Alzheimer’s, and if the tests we have measure it accurately. The purpose of this study therefore, is to gather blood samples and information from patients about their levels of cortisol in their blood and to see how this relates to stress and anxiety. We will recruit 10 people with Parkinson's, 10 with early Alzheimer's and 10 healthy controls. We will take three blood samples at 11am, 1pm and 3pm on three separate days over a fortnight. We will also assess things that can affect cortisol levels e.g. age, medications, sleep, and anxiety. We will analyse the blood cortisol levels and see how they relate to the other questionnaires.
REC Name East of England - Cambridge Central Research Ethics Committee
REC Reference 16/EE/0210
REC Opinion

Further Information Favourable Opinion

Further Information Favourable Opinion

Date of REC Opinion 26 July 2016