National Young Stroke Study
Research type
Research Study
Full title
The National Young Stroke Study
IRAS ID
328197
Contact name
Linxin Li
Contact email
Sponsor organisation
University of Oxford/Research Governance, Ethics and Assurance
Duration of Study in the UK
29 years, 11 months, 31 days
Research summary
The number of new stroke cases diagnosed yearly has declined at older ages. However, over the last 10 to 20 years the number has been doubling in those aged less than 55 years (“young stroke”). There are now 20,000 new “young stroke” cases every year in the UK. Unfortunately, we still do not know the reasons behind this increase. There is, therefore, an urgent need to better understand the causes and routes to prevention of stroke at younger ages.
One of the main barriers to effective prevention of stroke at younger ages is that the main mechanistic drivers are still unclear and there is also a lack of clinical data to test hypothesis.
The National Young Stroke Study (NYSS) is the first UK-wide study to look at the roles of both traditional modifiable risk factors (such as high blood pressure, diabetes, high cholesterol level, smoking, alcohol and obesity) and emerging risk factors (such as mental health conditions, stress, long working hours, and oral health) and young stroke. We will work with the NIHR Clinical Research Network to recruit patients (18-54 years) with acute stroke and compare the prevalence of the above risk factors in these young stroke patients to participants without stroke from the Health Survey for England, which has collected identical information on risk factors. For patients, in addition to collecting the above information through a questionnaire at baseline, the study also aims to perform administrative follow-up to assess what happens to these patients 20 or 30 years after their stroke, including looking at if they develop other conditions such as another stroke, heart attack, mental health conditions or dementia.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
24/NW/0003
Date of REC Opinion
18 Jan 2024
REC opinion
Favourable Opinion